Citation: Persson, L., B.M. Carney Almroth, C.D. Collins, S. Cornell, C.A. de Wit, M.L. Diamond, P. Fantke, M. Hassellöv, M. MacLeod, M.W. Ryberg, P. Søgaard Jørgensen, P. Villarrubia-Gómez, Z. Wang and M. Zwicky Hauschild. 2022. Response to comment on “Outside the safe operating space of the planetary boundary for novel entities.”. Environmental Science & Technology 56(10):6788–6789.